Depakote
indicated to manage seizures and moods.
Strengths: 125 · 250 · 500mg
Where to Check Availability
Medicine details
- Conditions
- Alternative names
Epilim
- Therapeutic class
Antiepileptic
- Pharmacological class
Histone deacetylase inhibitor
- Known off-label uses
migraine prophylaxis
- Contraindications
hepatic impairment; urea cycle disorders; porphyria
- Precautions and warnings
regular blood count monitoring recommended; may cause liver toxicity
- Minor side effects
nausea; tremor; somnolence
- Moderate side effects
ataxia; weight gain; alopecia
- Dosage forms
Gastro-resistant tablet
- Administration route
Oral use
- Patient summary
indicated to manage seizures and moods.
- Prescription status
POM
- Manufacturer
AbbVie
- Onset Time
1–2 weeks
- Duration
12–24 hours
- Storage instructions
Store in a cool, dry place.
- Drug interactions
aspirin; warfarin; phenytoin
Serious side effects
pancreatitis — requires immediate medical attention; hepatotoxicity — requires immediate medical attention
Mechanism of action
Valproate acts by increasing the concentration of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, which stabilizes electrical activity and balances mood regulation.
Age restrictions
High risk in pregnancy (avoid in females of childbearing potential unless no other treatment is effective).
Pregnancy and breastfeeding
Pregnancy: Strictly contraindicated due to risk of birth defects. Breastfeeding: Generally not recommended.
Depakote
indicated to manage seizures and moods.
Editorial Notes
- Active ingredient(s): Valproic Acid
- Listed indication(s): Epilepsy, Bipolar Disorder
Usually available as
- 360 tablets - 125 mg384-125-mg-4775
- 120 tablets - 250 mg384-250-mg-2668
- 60 tablets - 500 mg384-500-mg-2671