Valparin

Utilized to manage seizures and stabilize mood, formulated to target neurological hyperexcitability and support better physiological function in patients.

Strengths: 250 · 500 · 750mg

Neurology icon Neurology Valproic Acid icon Valproic Acid

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Medicine details

Conditions
Alternative names

Epilim; Depakote

Therapeutic class

Antiepileptic

Pharmacological class

Carboxylic acid

Known off-label uses

neuropathic pain

Minor side effects

nausea; tremor; drowsiness

Moderate side effects

weight gain; alopecia; thrombocytopenia

Dosage forms

Tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Sun Pharma

Onset Time

1–4 weeks

Duration

12–24 hours

Storage instructions

Store in a cool, dry place away from direct sunlight.

Drug interactions

Alcohol; carbamazepine; phenytoin; aspirin

Age restrictions

Use with caution in children and adolescents; monitor for hepatotoxicity.

Contraindications

hypersensitivity to valproic acid; active liver disease; history of severe hepatic impairment; urea cycle disorders; porphyria; pregnancy

Precautions and warnings

regular monitoring of liver function required; may impair ability to drive or operate machinery

Serious side effects

hepatotoxicity — requires immediate medical attention; pancreatitis — requires immediate medical attention; anaphylaxis — requires immediate medical attention

Patient summary

Utilized to manage seizures and stabilize mood, formulated to target neurological hyperexcitability and support better physiological function in patients.

Mechanism of action

Valproic acid increases the concentration of gamma-aminobutyric acid (GABA) in the brain. It also blocks voltage-gated sodium channels and T-type calcium channels, stabilizing nerve membranes and reducing excessive electrical activity associated with convulsions and mood dysregulation.

Pregnancy and breastfeeding

Valproic acid must not be used during pregnancy due to high risk of birth defects and developmental disorders. Effective contraception is essential.

Valparin

Utilized to manage seizures and stabilize mood, formulated to target neurological hyperexcitability and support better physiological function in patients.

Editorial Notes

  • Active ingredient(s): Valproic Acid
  • Listed indication(s): Epilepsy, Bipolar Disorder, Migraine Prophylaxis

Usually available as

  • 30 tablets - 250 mg219-250-mg-160
  • 30 tablets - 500 mg219-500-mg-163
  • 30 tablets - 750 mg219-750-mg-165