Topamax
Designed to support the management of epilepsy and migraine, this therapeutic agent is indicated to alleviate seizure frequency and headache severity.
Strengths: 25 · 50 · 100mg
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Medicine details
- Conditions
- Therapeutic class
Antiepileptic
- Pharmacological class
Sulfamate-substituted Monosaccharide
- Contraindications
hypersensitivity to topiramate
- Minor side effects
paraesthesia; anorexia; weight loss; fatigue
- Moderate side effects
memory impairment; speech disorders; depression
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Janssen-Cilag
- Onset Time
2–3 hours
- Duration
20–30 hours
- Storage instructions
Store below 25°C in a dry place.
- Drug interactions
valproate; phenytoin; carbamazepine
- Age restrictions
Not recommended for children under 2 years.
Precautions and warnings
maintain adequate hydration; monitor for mood changes; risk of angle-closure glaucoma
Serious side effects
nephrolithiasis — requires immediate medical attention; suicidal ideation — requires immediate medical attention; metabolic acidosis — requires immediate medical attention
Patient summary
Designed to support the management of epilepsy and migraine, this therapeutic agent is indicated to alleviate seizure frequency and headache severity.
Mechanism of action
Topiramate works through multiple mechanisms: it blocks voltage-gated sodium channels, enhances GABA activity (an inhibitory neurotransmitter), and antagonizes glutamate receptors to suppress neuronal hyperexcitability.
Pregnancy and breastfeeding
Pregnancy: Fetal risk identified; avoid. Breastfeeding: Excreted in milk; monitoring required.
Topamax
Designed to support the management of epilepsy and migraine, this therapeutic agent is indicated to alleviate seizure frequency and headache severity.
Editorial Notes
- Active ingredient(s): Topiramate
- Listed indication(s): Epilepsy, Migraine Prophylaxis
Usually available as
- 180 tablets - 25 mg144-25-mg-4342
- 90 tablets - 50 mg144-50-mg-4346
- 60 tablets - 100 mg144-100-mg-1518