Topiramate Tablets

designed to mitigate frequency of seizures and migraines to support overall neurological stability.

Strengths: 25 · 50 · 100 · 200mg

Medicine details

Alternative names

Topamax

Therapeutic class

Antiepileptic

Pharmacological class

Sulfamate-substituted monosaccharide

Contraindications

hypersensitivity to topiramate; pregnancy (for migraine prophylaxis)

Minor side effects

paresthesia; anorexia; weight loss; taste perversion

Moderate side effects

cognitive impairment; dizziness; fatigue; nausea

Dosage forms

Film-coated tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Janssen-Cilag

Onset Time

2–4 weeks

Duration

long-term

Storage instructions

Keep dry below 25°C.

Drug interactions

oral contraceptives; CNS depressants; other antiepileptics

Age restrictions

Use with caution in children.

Precautions and warnings

maintain adequate hydration to prevent kidney stones; may impair cognitive function; monitor for vision changes

Serious side effects

glaucoma — requires immediate medical attention; metabolic acidosis — requires immediate medical attention; nephrolithiasis — requires immediate medical attention

Patient summary

designed to mitigate frequency of seizures and migraines to support overall neurological stability.

Mechanism of action

Topiramate works by blocking voltage-dependent sodium channels, augmenting GABA-induced inhibition, and antagonizing glutamate activity. This multi-faceted mechanism reduces neuronal excitability, preventing the abnormal electrical activity that causes seizures and migraine auras.

Pregnancy and breastfeeding

Pregnancy: High risk of birth defects; do not use for migraine prevention. Breastfeeding: Not recommended.

Topiramate Tablets

designed to mitigate frequency of seizures and migraines to support overall neurological stability.

Editorial Notes

  • Active ingredient(s): Topiramate
  • Listed indication(s): Epilepsy, Migraine Prophylaxis

Usually available as

  • 180 tablets - 25 mg1208-25-mg-14343
  • 90 tablets - 50 mg1208-50-mg-14347
  • 90 tablets - 100 mg1208-100-mg-14329