Simvastatin Tablets
indicated to lower lipid levels to manage cardiovascular disease risks.
Strengths: 5 · 10 · 20 · 40mg
Where to Check Availability
Medicine details
- Alternative names
Zocor
- Therapeutic class
HMG-CoA reductase inhibitor
- Pharmacological class
Statin
- Precautions and warnings
monitor muscle pain; regular liver function tests may be required
- Minor side effects
headache; abdominal pain; constipation
- Moderate side effects
myalgia; elevated liver enzymes
- Serious side effects
rhabdomyolysis — requires immediate medical attention
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Patient summary
indicated to lower lipid levels to manage cardiovascular disease risks.
- Prescription status
POM
- Manufacturer
Organon
- Onset Time
2–4 weeks
- Duration
24 hours
- Storage instructions
Store below 30°C, keep dry.
- Drug interactions
grapefruit; ciclosporin; warfarin; verapamil
- Age restrictions
Not for use in children.
Contraindications
active liver disease; pregnancy; breastfeeding; concurrent use of strong CYP3A4 inhibitors
Mechanism of action
Simvastatin inhibits the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver, effectively lowering total and LDL cholesterol levels in the blood.
Pregnancy and breastfeeding
Pregnancy: contraindicated due to potential risk of fetal harm. Breastfeeding: contraindicated.
Simvastatin Tablets
indicated to lower lipid levels to manage cardiovascular disease risks.
Editorial Notes
- Active ingredient(s): Simvastatin
- Listed indication(s): Hypercholesterolaemia, Cardiovascular Disease Prevention
Usually available as
- 180 tablets - 5 mg1341-5-mg-16172
- 120 tablets - 10 mg1341-10-mg-16177
- 90 tablets - 20 mg1341-20-mg-16183