Zocor
Indicated to support the reduction of cholesterol levels, formulated to mitigate cardiovascular risk by inhibiting a key enzyme in cholesterol synthesis.
Strengths: 5 · 10 · 20 · 40mg
Where to Check Availability
Medicine details
- Therapeutic class
HMG-CoA Reductase Inhibitor
- Pharmacological class
Statin
- Contraindications
hypersensitivity to simvastatin; active liver disease; pregnancy; breastfeeding
- Minor side effects
headache; constipation; nausea
- Moderate side effects
myalgia; abdominal pain; dizziness
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
MSD
- Onset Time
2 weeks
- Duration
4–6 weeks
- Storage instructions
Store below 30°C.
- Drug interactions
grapefruit juice; amiodarone; verapamil
- Age restrictions
Typically for adults.
- Pregnancy and breastfeeding
Pregnancy: contra-indicated. Breastfeeding: contra-indicated.
Precautions and warnings
report unexplained muscle pain immediately; regular liver function monitoring advised
Serious side effects
rhabdomyolysis — requires immediate medical attention; myopathy — requires immediate medical attention; hepatitis — requires immediate medical attention
Patient summary
Indicated to support the reduction of cholesterol levels, formulated to mitigate cardiovascular risk by inhibiting a key enzyme in cholesterol synthesis.
Mechanism of action
Simvastatin is an HMG-CoA reductase inhibitor. It competitively inhibits the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate, the rate-limiting step in cholesterol biosynthesis in the liver.
Zocor
Indicated to support the reduction of cholesterol levels, formulated to mitigate cardiovascular risk by inhibiting a key enzyme in cholesterol synthesis.
Editorial Notes
- Active ingredient(s): Simvastatin
- Listed indication(s): Hypercholesterolaemia, Coronary Heart Disease
Usually available as
- 180 tablets - 5 mg248-5-mg-4630
- 120 tablets - 10 mg248-10-mg-4635
- 90 tablets - 20 mg248-20-mg-4641