Crestor
intended to target elevated cholesterol levels within the blood to manage cardiovascular risk.
Strengths: 5 · 10 · 20mg
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Medicine details
- Therapeutic class
HMG-CoA Reductase Inhibitor
- Pharmacological class
Statin
- Contraindications
active liver disease; pregnancy; breastfeeding
- Precautions and warnings
monitor liver enzymes; report unexplained muscle pain
- Minor side effects
headache; nausea; myalgia
- Moderate side effects
dizziness; constipation; abdominal pain
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
AstraZeneca
- Onset Time
1–2 weeks
- Duration
24 hours
- Storage instructions
Store at room temperature, away from light.
- Drug interactions
ciclosporin; vitamin k antagonists
- Age restrictions
Used in children ≥6 years for heterozygous familial hypercholesterolaemia.
- Pregnancy and breastfeeding
Contraindicated in pregnancy. Breastfeeding contraindicated.
Serious side effects
rhabdomyolysis — requires immediate medical attention; myopathy — requires immediate medical attention
Patient summary
intended to target elevated cholesterol levels within the blood to manage cardiovascular risk.
Mechanism of action
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol.
Crestor
intended to target elevated cholesterol levels within the blood to manage cardiovascular risk.
Editorial Notes
- Active ingredient(s): Rosuvastatin
- Listed indication(s): Hypercholesterolaemia, Cardiovascular Risk Reduction
Usually available as
- 90 tablets - 5 mg22-5-mg-2602
- 60 tablets - 10 mg22-10-mg-972
- 30 tablets - 20 mg22-20-mg-976