Metformin + Glyburide Tablets

Formulated to target blood glucose, utilized to manage type 2 diabetes mellitus.

Strengths: 2.5/400 · 5/500mg

Medicine details

Alternative names

Glucovance

Therapeutic class

Biguanide and Sulphonylurea Combination

Pharmacological class

Antidiabetic

Contraindications

diabetic ketoacidosis; severe renal insufficiency

Precautions and warnings

monitor blood glucose; risk of hypoglycaemia

Minor side effects

nausea; diarrhoea

Moderate side effects

hypoglycaemia; abdominal discomfort

Dosage forms

Film-coated tablet

Administration route

Oral use

Patient summary

Formulated to target blood glucose, utilized to manage type 2 diabetes mellitus.

Prescription status

POM

Manufacturer

Merck

Onset Time

1–2 hours

Duration

12–24 hours

Storage instructions

Store in a dry place below 25°C.

Drug interactions

alcohol; corticosteroids

Serious side effects

lactic acidosis — requires immediate medical attention; severe hypoglycaemia — requires immediate medical attention

Mechanism of action

This combination provides dual therapy: metformin decreases hepatic glucose production and increases insulin sensitivity, while glibenclamide stimulates pancreatic insulin secretion from beta cells.

Pregnancy and breastfeeding

Pregnancy: Not recommended; insulin is preferred. Breastfeeding: Not recommended.

Metformin + Glyburide Tablets

Formulated to target blood glucose, utilized to manage type 2 diabetes mellitus.

Editorial Notes

  • Active ingredient(s): Metformin, Glibenclamide
  • Listed indication(s): Type 2 Diabetes Mellitus