Glucovance

Designed to manage type 2 diabetes mellitus to support insulin sensitivity and blood glucose regulation.

Strengths: 400/2.50 · 500/5mg

Diabetes Management icon Diabetes Management Metformin icon Metformin Glibenclamide icon Glibenclamide

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Medicine details

Conditions
Alternative names

Metformin + Glyburide Tablets

Therapeutic class

Biguanide Antidiabetic; Sulfonylurea

Pharmacological class

Biguanide; Sulfonylurea

Contraindications

hypersensitivity; severe renal impairment; diabetic ketoacidosis; diabetic coma

Precautions and warnings

monitor kidney function regularly; risk of lactic acidosis

Minor side effects

nausea; diarrhoea; abdominal pain

Moderate side effects

hypoglycaemia; headache; dizziness

Dosage forms

Film-coated tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Merck Serono

Onset Time

1–2 hours

Duration

12–24 hours

Storage instructions

Store in a cool, dry place away from direct light and moisture.

Drug interactions

Alcohol; Cimetidine

Age restrictions

Not indicated for use in children.

Serious side effects

lactic acidosis — requires immediate medical attention; anaphylaxis — requires immediate medical attention

Patient summary

Designed to manage type 2 diabetes mellitus to support insulin sensitivity and blood glucose regulation.

Mechanism of action

This medicine combines two active agents: one that lowers liver glucose production and intestinal absorption, and another that stimulates the pancreas to release more insulin. Together, they help maintain balanced blood sugar levels in patients who have not achieved adequate control through diet or exercise alone.

Pregnancy and breastfeeding

Pregnancy: Use is generally avoided; insulin is preferred for blood glucose control. Breastfeeding: Not recommended as safety data is limited.

Glucovance

Designed to manage type 2 diabetes mellitus to support insulin sensitivity and blood glucose regulation.

Editorial Notes

  • Active ingredient(s): Metformin, Glibenclamide
  • Listed indication(s): Type 2 Diabetes Mellitus

Usually available as

  • 180 tablets - 400/2.50 mg260-400-2-50-mg-3110
  • 120 tablets - 500/5 mg260-500-5-mg-3116