Tamoxifen Tablets
Indicated to support to mitigate breast cancer progression, utilized in patients requiring hormonal manipulation for effective disease management.
Strengths: 10 · 20mg
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Medicine details
- Alternative names
Nolvadex
- Therapeutic class
Selective oestrogen receptor modulator (SERM)
- Pharmacological class
SERM
- Known off-label uses
infertility
- Contraindications
pregnancy; history of deep vein thrombosis; history of pulmonary embolism
- Minor side effects
hot flushes; nausea; fatigue; vaginal discharge
- Moderate side effects
fluid retention; alopecia; skin rash
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
AstraZeneca
- Onset Time
4–8 weeks
- Duration
2–5 years
- Storage instructions
Store below 25°C in a dry place.
- Drug interactions
warfarin; rifampicin; paroxetine
- Age restrictions
Not licensed for use in children.
Precautions and warnings
risk of thromboembolic events; endometrial monitoring advised for persistent vaginal bleeding
Serious side effects
thromboembolism — requires immediate medical attention; endometrial cancer — requires immediate medical attention
Patient summary
Indicated to support to mitigate breast cancer progression, utilized in patients requiring hormonal manipulation for effective disease management.
Mechanism of action
Tamoxifen acts as a selective oestrogen receptor modulator. It binds to oestrogen receptors in breast tissue, competitively inhibiting the binding of oestradiol, which prevents the oestrogen-stimulated proliferation of cancer cells.
Pregnancy and breastfeeding
Pregnancy: Contraindicated; must rule out pregnancy before treatment. Breastfeeding: Avoid breastfeeding.
Tamoxifen Tablets
Indicated to support to mitigate breast cancer progression, utilized in patients requiring hormonal manipulation for effective disease management.
Editorial Notes
- Active ingredient(s): Tamoxifen
- Listed indication(s): Breast Cancer, Oestrogen Receptor Positive Breast Cancer
Usually available as
- 360 tablets - 10 mg1191-10-mg-14095
- 360 tablets - 20 mg1191-20-mg-14101