Nolvadex
formulated to manage hormone-receptor-positive breast cancer and to support treatment outcomes through oestrogen receptor inhibition.
Strengths: 10 · 20mg
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Medicine details
- Conditions
- Therapeutic class
Selective oestrogen Receptor Modulator
- Pharmacological class
SERM
- Known off-label uses
infertility in women; gynaecomastia in men
- Contraindications
pregnancy; history of thromboembolic disorders; hypersensitivity to tamoxifen
- Minor side effects
hot flushes; nausea; fluid retention
- Moderate side effects
vaginal bleeding; endometrial changes; vision disturbances
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
AstraZeneca
- Onset Time
2–4 weeks
- Duration
Daily
- Drug interactions
warfarin; rifampicin; letrozole
- Age restrictions
For adults; not intended for paediatric use.
Precautions and warnings
monitor for visual disturbances; report any abnormal vaginal bleeding; not recommended for use with blood-thinning medication
Serious side effects
thromboembolism — requires immediate medical attention; uterine cancer — requires immediate medical attention; stroke — requires immediate medical attention
Patient summary
formulated to manage hormone-receptor-positive breast cancer and to support treatment outcomes through oestrogen receptor inhibition.
Mechanism of action
Nolvadex functions by binding to the oestrogen receptors in breast tissue. This prevents oestrogen from attaching, which can slow or stop the growth of breast cancer cells that rely on this hormone to develop.
Storage instructions
Store at room temperature, keep in original packaging, away from moisture and direct light.
Pregnancy and breastfeeding
Pregnancy: Must not be used during pregnancy as it may cause fetal harm. Breastfeeding: Must not be used while breastfeeding as the drug is excreted into milk.
Nolvadex
formulated to manage hormone-receptor-positive breast cancer and to support treatment outcomes through oestrogen receptor inhibition.
Editorial Notes
- Active ingredient(s): Tamoxifen
- Listed indication(s): Breast Cancer
Usually available as
- 360 tablets - 10 mg275-10-mg-5118
- 180 tablets - 20 mg275-20-mg-5126