Rapamycin
Developed to target the immune response and indicated to support transplant success, this agent is utilized to alleviate the risk of organ rejection.
Strengths: 1mg
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Medicine details
- Conditions
- Alternative names
Rapamune
- Therapeutic class
Immunosuppressant
- Pharmacological class
mTOR inhibitor
- Contraindications
hypersensitivity to sirolimus; pregnancy; breastfeeding
- Minor side effects
nausea; diarrhoea; acne
- Moderate side effects
hyperlipidaemia; thrombocytopenia; peripheral oedema
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Pfizer
- Onset Time
3–5 days
- Duration
long-term
- Storage instructions
Store in refrigerator (2°C–8°C), protected from light.
- Drug interactions
cyclosporin; grapefruit; rifampicin
- Age restrictions
Consult specialist for paediatric usage.
Precautions and warnings
regular blood level monitoring required; avoid live vaccines; use effective contraception
Serious side effects
pneumonitis — requires immediate medical attention; lymphoma — requires immediate medical attention; renal impairment — requires immediate medical attention
Patient summary
Developed to target the immune response and indicated to support transplant success, this agent is utilized to alleviate the risk of organ rejection.
Mechanism of action
Sirolimus acts as an mTOR inhibitor that prevents the activation of T-cells and B-cells in response to cytokine stimulation. By blocking this cell cycle progression, it effectively prevents the immunological mechanisms that cause organ rejection.
Pregnancy and breastfeeding
Pregnancy: Must not be used in pregnancy. Breastfeeding: Must not be used while breastfeeding.
Rapamycin
Developed to target the immune response and indicated to support transplant success, this agent is utilized to alleviate the risk of organ rejection.
Editorial Notes
- Active ingredient(s): Sirolimus
- Listed indication(s): Transplant Rejection
Available option
- 30 tablets - 1 mg1445-1-mg-17436