Nizoral
This treatment is utilized to mitigate severe systemic fungal conditions and designed to address hormone-related pathologies such as cushing's syndrome.
Strengths: 200mg
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Medicine details
- Therapeutic class
Antifungal
- Pharmacological class
Imidazole
- Precautions and warnings
monitor liver function tests; monitor for signs of adrenal insufficiency
- Minor side effects
nausea; diarrhoea; headache; dizziness
- Moderate side effects
gynaecomastia; menstrual abnormalities
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Janssen-Cilag
- Onset Time
1–2 weeks
- Duration
ongoing
- Storage instructions
Store at room temperature away from moisture.
- Drug interactions
Alcohol; Antacids; Proton pump inhibitors; Warfarin
- Age restrictions
Not recommended for children.
Contraindications
hypersensitivity to imidazole; acute or chronic liver disease; concurrent use of cisapride; concurrent use of terfenadine
Serious side effects
hepatotoxicity — requires immediate medical attention; adrenal insufficiency — requires immediate medical attention
Patient summary
This treatment is utilized to mitigate severe systemic fungal conditions and designed to address hormone-related pathologies such as cushing's syndrome.
Mechanism of action
Ketoconazole inhibits the cytochrome P450-dependent synthesis of ergosterol in fungal cell membranes. It also possesses a secondary pharmacological effect of inhibiting adrenal steroid biosynthesis, which is how it is used to manage high cortisol levels.
Pregnancy and breastfeeding
Pregnancy: contraindicated. Breastfeeding: breastfeeding must be discontinued during treatment.
Nizoral
This treatment is utilized to mitigate severe systemic fungal conditions and designed to address hormone-related pathologies such as cushing’s syndrome.
Editorial Notes
- Active ingredient(s): Ketoconazole
- Listed indication(s): Cushing’s Syndrome, Severe Systemic Fungal Infections
Available option
- 60 tablets - 200 mg94-200-mg-1321