Grisactin

This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.

Strengths: 250mg

Medicine details

Conditions
Alternative names

Fulcin

Therapeutic class

Antifungal

Pharmacological class

Benzofuran

Minor side effects

nausea; diarrhoea; headache; fatigue

Moderate side effects

rash; urticaria

Dosage forms

Tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Wyeth

Onset Time

1–2 weeks

Duration

4–8 weeks

Storage instructions

Store in a cool, dry place away from direct light.

Drug interactions

Alcohol; Warfarin; Oral contraceptives; Ciclosporin

Age restrictions

Use with caution in children.

Contraindications

hypersensitivity to griseofulvin; porphyria; severe hepatic impairment; systemic lupus erythematosus

Precautions and warnings

avoid pregnancy during treatment and for one month after; caution in patients with liver disease; regular monitoring of blood counts and liver function recommended

Serious side effects

hepatotoxicity — requires immediate medical attention; leukopenia — requires immediate medical attention; photosensitivity — requires immediate medical attention

Patient summary

This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.

Mechanism of action

Griseofulvin works by depositing itself within keratin precursor cells, making them resistant to fungal invasion. It inhibits fungal cell mitosis by disrupting the mitotic spindle, effectively stopping the growth and replication of dermatophyte fungi such as Trichophyton, Microsporum, and Epidermophyton species.

Pregnancy and breastfeeding

Pregnancy: strictly contraindicated. Breastfeeding: not recommended due to lack of safety data.

Grisactin

This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.

Editorial Notes

  • Active ingredient(s): Griseofulvin
  • Listed indication(s): Dermatophytosis

Available option

  • 180 tablets - 250 mg92-250-mg-3135