Grisactin
This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.
Strengths: 250mg
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Medicine details
- Conditions
- Alternative names
Fulcin
- Therapeutic class
Antifungal
- Pharmacological class
Benzofuran
- Minor side effects
nausea; diarrhoea; headache; fatigue
- Moderate side effects
rash; urticaria
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Wyeth
- Onset Time
1–2 weeks
- Duration
4–8 weeks
- Storage instructions
Store in a cool, dry place away from direct light.
- Drug interactions
Alcohol; Warfarin; Oral contraceptives; Ciclosporin
- Age restrictions
Use with caution in children.
Contraindications
hypersensitivity to griseofulvin; porphyria; severe hepatic impairment; systemic lupus erythematosus
Precautions and warnings
avoid pregnancy during treatment and for one month after; caution in patients with liver disease; regular monitoring of blood counts and liver function recommended
Serious side effects
hepatotoxicity — requires immediate medical attention; leukopenia — requires immediate medical attention; photosensitivity — requires immediate medical attention
Patient summary
This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.
Mechanism of action
Griseofulvin works by depositing itself within keratin precursor cells, making them resistant to fungal invasion. It inhibits fungal cell mitosis by disrupting the mitotic spindle, effectively stopping the growth and replication of dermatophyte fungi such as Trichophyton, Microsporum, and Epidermophyton species.
Pregnancy and breastfeeding
Pregnancy: strictly contraindicated. Breastfeeding: not recommended due to lack of safety data.
Grisactin
This medicine is formulated to address persistent fungal skin infections and intended to mitigate the spread of dermatophytes on the skin, nails, or scalp.
Editorial Notes
- Active ingredient(s): Griseofulvin
- Listed indication(s): Dermatophytosis
Available option
- 180 tablets - 250 mg92-250-mg-3135