Leukeran
Utilized to manage specific types of blood cancers, formulated to slow the progression of malignant cellular growth in the lymphatic system.
Strengths: 2 · 5mg
Where to Check Availability
Medicine details
- Therapeutic class
Alkylating Agent
- Pharmacological class
Nitrogen Mustard Derivative
- Contraindications
hypersensitivity to chlorambucil; severe bone marrow suppression
- Minor side effects
nausea; vomiting; diarrhoea
- Moderate side effects
bone marrow suppression; stomatitis; elevated liver enzymes
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Aspen Pharma
- Onset Time
1–2 weeks
- Duration
3–4 weeks
- Storage instructions
Store in a refrigerator at 2°C to 8°C. Keep in original packaging.
- Drug interactions
live vaccines
- Age restrictions
Not recommended for paediatric use.
Precautions and warnings
regular blood monitoring required during treatment; monitor for signs of infection
Serious side effects
secondary malignancies — requires immediate medical attention; interstitial lung disease — requires immediate medical attention; seizures — requires immediate medical attention
Patient summary
Utilized to manage specific types of blood cancers, formulated to slow the progression of malignant cellular growth in the lymphatic system.
Mechanism of action
Chlorambucil is an alkylating agent. It binds to DNA within cells, causing cross-linking that prevents DNA replication and cell division. This process effectively inhibits the proliferation of abnormal, rapidly dividing cancerous cells, particularly those involved in lymphocytic disorders.
Pregnancy and breastfeeding
Pregnancy: must not be used during pregnancy. Breastfeeding: breastfeeding must be discontinued during treatment.
Leukeran
Utilized to manage specific types of blood cancers, formulated to slow the progression of malignant cellular growth in the lymphatic system.
Editorial Notes
- Active ingredient(s): Chlorambucil
- Listed indication(s): Chronic Lymphocytic Leukaemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma
Usually available as
- 30 tablets - 2 mg237-2-mg-1218
- 30 tablets - 5 mg237-5-mg-6376