Alkacel
Formulated to address malignant cell proliferation by supporting the alkylation of DNA and inhibiting cellular replication.
Strengths: 2mg
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Medicine details
- Conditions
- Alternative names
Alkeran
- Therapeutic class
Antineoplastic Agent; Alkylating Agent
- Pharmacological class
Nitrogen Mustard
- Contraindications
hypersensitivity to melphalan; severe bone marrow suppression
- Minor side effects
nausea; vomiting; alopecia
- Moderate side effects
anaemia; leukopenia; thrombocytopenia; stomatitis
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Celon Laboratories
- Onset Time
N/A
- Duration
N/A
- Storage instructions
Store at 2–8°C.
- Drug interactions
ciclosporin; nalidixic acid
- Age restrictions
Use with caution in children.
- Pregnancy and breastfeeding
Pregnancy: Contraindicated. Breastfeeding: Contraindicated.
Precautions and warnings
regular blood monitoring recommended; avoid conception during treatment; risk of secondary malignancy
Serious side effects
bone marrow failure — requires immediate medical attention; pulmonary fibrosis — requires immediate medical attention
Patient summary
Formulated to address malignant cell proliferation by supporting the alkylation of DNA and inhibiting cellular replication.
Mechanism of action
Melphalan is a bifunctional alkylating agent that creates cross-links in DNA strands, which interferes with DNA replication and transcription, ultimately inducing apoptosis in malignant cells.
Alkacel
Formulated to address malignant cell proliferation by supporting the alkylation of DNA and inhibiting cellular replication.
Editorial Notes
- Active ingredient(s): Melphalan
- Listed indication(s): Multiple Myeloma, Ovarian Cancer
Available option
- 25 tablets - 2 mg1024-2-mg-12849