Indomethacin Tablets

Indicated to mitigate inflammation and developed to alleviate chronic pain, this medication is utilized to support mobility in arthritic conditions.

Strengths: 25 · 50 · 75mg

Pain Management icon Pain Management Indometacin icon Indometacin

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Medicine details

Conditions
Therapeutic class

Non-steroidal anti-inflammatory drug (NSAID)

Pharmacological class

Indoleacetic acid derivative

Minor side effects

nausea; dyspepsia; headache

Moderate side effects

dizziness; tinnitus; peripheral oedema

Dosage forms

Tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Teva UK Limited

Onset Time

30–60 minutes

Duration

4–6 hours

Storage instructions

Store at room temperature, protected from light.

Drug interactions

warfarin; methotrexate; lithium

Age restrictions

Not indicated for children.

Contraindications

history of gastrointestinal bleeding; active peptic ulcer; severe heart failure; severe renal impairment

Precautions and warnings

take with food to minimize stomach irritation; use with caution in the elderly; discontinue if gastrointestinal symptoms occur

Serious side effects

gastrointestinal haemorrhage — requires immediate medical attention; myocardial infarction — requires immediate medical attention; anaphylaxis — requires immediate medical attention

Patient summary

Indicated to mitigate inflammation and developed to alleviate chronic pain, this medication is utilized to support mobility in arthritic conditions.

Mechanism of action

Indometacin inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins from arachidonic acid. Decreasing prostaglandin levels reduces the inflammatory response and perception of pain in the body.

Pregnancy and breastfeeding

Pregnancy: Use is usually avoided, especially in the third trimester. Breastfeeding: Use with caution; monitor infant for side effects.

Indomethacin Tablets

Indicated to mitigate inflammation and developed to alleviate chronic pain, this medication is utilized to support mobility in arthritic conditions.

Editorial Notes

  • Active ingredient(s): Indometacin
  • Listed indication(s): Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Acute Gouty Arthritis

Usually available as

  • 360 tablets - 25 mg1397-25-mg-16755
  • 270 tablets - 50 mg1397-50-mg-16770
  • 90 tablets - 75 mg1397-75-mg-16764