Fluorouracil Cream
This topical treatment is indicated to target precancerous skin lesions and certain carcinomas, formulated to alleviate damaged cell growth.
Strengths: 1 · 5%
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Medicine details
- Conditions
- Alternative names
Efudix
- Therapeutic class
Antimetabolite
- Pharmacological class
Pyrimidine Analogue
- Known off-label uses
viral warts
- Contraindications
pregnancy; hypersensitivity to fluorouracil
- Minor side effects
erythema; burning; pruritus
- Moderate side effects
skin ulceration; dermatitis; pain
- Serious side effects
severe skin necrosis — requires immediate medical attention
- Dosage forms
Cream
- Administration route
Cutaneous use
- Prescription status
POM
- Manufacturer
Meda Pharmaceuticals
- Onset Time
days to weeks
- Duration
duration of course
- Storage instructions
Store in a cool, dry place.
- Age restrictions
Not for use in children.
Precautions and warnings
avoid contact with eyes and mucous membranes; use sunscreen whilst using treatment; apply sparingly; skin irritation is expected
Patient summary
This topical treatment is indicated to target precancerous skin lesions and certain carcinomas, formulated to alleviate damaged cell growth.
Mechanism of action
Fluorouracil is an antimetabolite that acts as an uracil analogue. It inhibits thymidylate synthase, thus interfering with DNA synthesis in rapidly dividing cells, forcing cell death in the affected skin lesions.
Pregnancy and breastfeeding
Pregnancy: Contraindicated; causes fetal malformation. Breastfeeding: Not recommended.
Fluorouracil Cream
This topical treatment is indicated to target precancerous skin lesions and certain carcinomas, formulated to alleviate damaged cell growth.
Editorial Notes
- Active ingredient(s): Fluorouracil
- Listed indication(s): Actinic Keratosis, Basal Cell Carcinoma
Available option
- 5 tubes - 5 %1170-5-pct-13855