Chlorambucil Tablets
Developed to target malignancy, utilized to manage symptoms of chronic lymphoid conditions.
Strengths: 2 · 5mg
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Medicine details
- Alternative names
Leukeran
- Therapeutic class
Alkylating Agent
- Pharmacological class
Nitrogen Mustard
- Contraindications
severe bone marrow suppression; hypersensitivity
- Precautions and warnings
regular blood counts required; avoid live vaccines
- Minor side effects
nausea; fatigue
- Moderate side effects
leukopenia; thrombocytopenia
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Aspen Pharma
- Storage instructions
Store in a refrigerator (2°C–8°C).
- Drug interactions
immunosuppressants
- Pregnancy and breastfeeding
Pregnancy: Do not use. Breastfeeding: Do not use.
Serious side effects
bone marrow failure — requires immediate medical attention; secondary malignancy — requires immediate medical attention
Patient summary
Developed to target malignancy, utilized to manage symptoms of chronic lymphoid conditions.
Mechanism of action
Chlorambucil is a bifunctional alkylating agent that creates cross-links between DNA strands, inhibiting DNA replication and transcription, which prevents rapidly dividing cancer cells from proliferating.
Chlorambucil Tablets
Developed to target malignancy, utilized to manage symptoms of chronic lymphoid conditions.
Editorial Notes
- Active ingredient(s): Chlorambucil
- Listed indication(s): Chronic Lymphocytic Leukaemia, Non-hodgkin Lymphoma
Usually available as
- 30 tablets - 2 mg1180-2-mg-13962
- 30 tablets - 5 mg1180-5-mg-13967