Spironolactone Tablets
Developed to manage oedema associated with congestive heart failure and to support blood pressure regulation by increasing salt and water excretion.
Strengths: 25 · 100mg
Where to Check Availability
Medicine details
- Alternative names
Aldactone
- Therapeutic class
Aldosterone Antagonist
- Pharmacological class
Potassium-Sparing Diuretic
- Contraindications
hypersensitivity to spironolactone; hyperkalaemia; severe renal impairment
- Minor side effects
dizziness; headache; nausea
- Moderate side effects
gynaecomastia; hyperkalaemia; fatigue
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Pfizer
- Onset Time
2–4 days
- Duration
constant
- Storage instructions
Store in a cool, dry place.
- Drug interactions
potassium salts; ace inhibitors; angiotensin ii receptor antagonists
- Age restrictions
Suitable for adults.
- Pregnancy and breastfeeding
Pregnancy: Use only if indicated. Breastfeeding: Use with caution.
Precautions and warnings
monitor potassium levels regularly; avoid potassium supplements; avoid excessive salt substitutes
Serious side effects
serious hyperkalaemia — requires immediate medical attention; arrhythmia — requires immediate medical attention
Patient summary
Developed to manage oedema associated with congestive heart failure and to support blood pressure regulation by increasing salt and water excretion.
Mechanism of action
Spironolactone is an aldosterone receptor antagonist. It acts on the distal renal tubules, increasing water and sodium excretion while reducing potassium excretion.
Spironolactone Tablets
Developed to manage oedema associated with congestive heart failure and to support blood pressure regulation by increasing salt and water excretion.
Editorial Notes
- Active ingredient(s): Spironolactone
- Listed indication(s): Hypertension, Oedema, Heart Failure, Hyperaldosteronism
Usually available as
- 360 tablets - 25 mg1141-25-mg-13523
- 120 tablets - 100 mg1141-100-mg-13527