Aldactone
Formulated to alleviate fluid retention, indicated to support blood pressure management and target mineralocorticoid receptors.
Strengths: 25 · 100mg
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Medicine details
- Conditions
- Therapeutic class
Diuretic
- Pharmacological class
Aldosterone Antagonist
- Known off-label uses
hirsutism
- Contraindications
hypersensitivity to spironolactone; Addison's disease; hyperkalaemia; anuria
- Minor side effects
headache; gastrointestinal disturbances; drowsiness
- Moderate side effects
gynaecomastia; menstrual irregularities; hyponatraemia
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Pfizer
- Onset Time
2–4 days
- Duration
2–3 days
- Storage instructions
Store below 25°C, protected from light.
- Drug interactions
potassium-sparing diuretics; ACE inhibitors
- Age restrictions
Use with caution in elderly patients.
- Pregnancy and breastfeeding
Use only if benefit outweighs risk.
Precautions and warnings
regular blood monitoring of potassium levels required; avoid excessive salt intake; may affect urination frequency
Serious side effects
severe hyperkalaemia — requires immediate medical attention; arrhythmia — requires immediate medical attention
Patient summary
Formulated to alleviate fluid retention, indicated to support blood pressure management and target mineralocorticoid receptors.
Mechanism of action
It serves as a competitive antagonist of aldosterone. By blocking the effects of aldosterone in the distal renal tubules, it increases sodium and water excretion while retaining potassium, which helps reduce excess fluid and pressure.
Aldactone
Formulated to alleviate fluid retention, indicated to support blood pressure management and target mineralocorticoid receptors.
Editorial Notes
- Active ingredient(s): Spironolactone
- Listed indication(s): Hypertension, Oedema, Heart Failure
Usually available as
- 360 tablets - 25 mg45-25-mg-1915
- 120 tablets - 100 mg45-100-mg-1919