Nintedanib Capsules
indicated to alleviate disease progression in idiopathic pulmonary fibrosis, to support respiratory function.
Strengths: 100mg
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Medicine details
- Conditions
- Alternative names
Ofev
- Therapeutic class
Tyrosine Kinase Inhibitor
- Pharmacological class
Tyrosine Kinase Inhibitor
- Contraindications
severe hepatic impairment; hypersensitivity to nintedanib
- Precautions and warnings
liver function must be monitored; avoid in patients with bleeding risk
- Minor side effects
diarrhoea; nausea; abdominal pain
- Moderate side effects
elevated liver enzymes; decreased appetite
- Dosage forms
Capsule, soft
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Boehringer Ingelheim
- Onset Time
variable
- Duration
long-term
- Storage instructions
Store below 25°C. Keep in original packaging.
- Drug interactions
rifampicin
- Age restrictions
Not for children.
Serious side effects
gastrointestinal perforation — requires immediate medical attention; arterial thromboembolism — requires immediate medical attention
Patient summary
indicated to alleviate disease progression in idiopathic pulmonary fibrosis, to support respiratory function.
Mechanism of action
Nintedanib is a small-molecule triple angiokinase inhibitor that blocks receptors involved in the processes of pulmonary fibrosis, thereby slowing disease progression.
Pregnancy and breastfeeding
Pregnancy: Contraindicated; use effective contraception. Breastfeeding: Not recommended.
Nintedanib Capsules
indicated to alleviate disease progression in idiopathic pulmonary fibrosis, to support respiratory function.
Editorial Notes
- Active ingredient(s): Nintedanib
- Listed indication(s): Idiopathic Pulmonary Fibrosis
Available option
- 30 capsules - 100 mg1273-100-mg-15186