Carbidopa + Levodopa Tablets
intended to manage parkinson's disease to address the loss of muscle control and motor symptoms.
Strengths: 10/100 · 25/100 · 25/250 · 50/200mg
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Medicine details
- Conditions
- Alternative names
Sinemet; Half Sinemet; Sinemet Cr
- Therapeutic class
Dopaminergic Agent
- Pharmacological class
Dopamine Precursor
- Minor side effects
nausea; dizziness; orthostatic hypotension; abnormal movements
- Moderate side effects
confusion; depression; insomnia; cardiac arrhythmia
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Merck Sharp & Dohme
- Onset Time
30–60 minutes
- Duration
3–5 hours
- Storage instructions
Store in a cool, dry place.
- Drug interactions
non-selective MAO inhibitors; antihypertensives; iron supplements
- Age restrictions
Not for use in children.
Contraindications
hypersensitivity to levodopa or carbidopa; narrow-angle glaucoma; concurrent use of non-selective MAO inhibitors
Precautions and warnings
may cause sudden sleep onset; regular blood pressure monitoring recommended; avoid high-protein meals with dose timing
Serious side effects
neuroleptic malignant syndrome — requires immediate medical attention; pathological gambling — requires immediate medical attention
Patient summary
intended to manage parkinson's disease to address the loss of muscle control and motor symptoms.
Mechanism of action
Levodopa is converted to dopamine in the brain, restoring levels of this essential neurotransmitter. Carbidopa prevents the peripheral breakdown of levodopa, so more of the drug reaches the brain and reducing systemic side effects.
Pregnancy and breastfeeding
Pregnancy: Use only if clearly indicated by a specialist. Breastfeeding: Not recommended.
Carbidopa + Levodopa Tablets
intended to manage parkinson’s disease to address the loss of muscle control and motor symptoms.
Editorial Notes
- Active ingredient(s): Carbidopa, Levodopa
- Listed indication(s): Parkinson’s Disease
Usually available as
- 180 tablets - 10/100 mg1202-10-100-mg-17364
- 120 tablets - 25/100 mg1202-25-100-mg-17357
- 90 tablets - 25/250 mg1202-25-250-mg-17350