Sinemet

Indicated to manage Parkinson's disease, this combination therapy is utilized to support motor function by replacing depleted dopamine in the central nervous system.

Strengths: 10/100 · 25/100 · 25/250mg

Neurology icon Neurology Carbidopa icon Carbidopa Levodopa icon Levodopa

Where to Check Availability

Medicine details

Conditions
Alternative names

Sinemet Cr; Carbidopa + Levodopa Tablets

Therapeutic class

Dopaminergic Agent

Pharmacological class

Decarboxylase Inhibitor/Dopamine Precursor

Minor side effects

dyskinesia; nausea; dizziness; dry mouth

Moderate side effects

orthostatic hypotension; confusion; insomnia

Dosage forms

Tablet; Prolonged-release tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

MSD

Onset Time

30–60 minutes

Duration

3–6 hours

Storage instructions

Store below 25°C in original packaging.

Drug interactions

antipsychotics; iron supplements; antihypertensives

Age restrictions

Not for paediatric use.

Pregnancy and breastfeeding

Pregnancy: Not recommended. Breastfeeding: Not recommended.

Contraindications

hypersensitivity to ingredients; narrow-angle glaucoma; concurrent use of non-selective mao inhibitors

Precautions and warnings

may cause sudden sleep onset; monitor for impulse control disorders; periodic haematological monitoring advised

Serious side effects

hallucinations — requires immediate medical attention; neuroleptic malignant syndrome — requires immediate medical attention

Patient summary

Indicated to manage Parkinson's disease, this combination therapy is utilized to support motor function by replacing depleted dopamine in the central nervous system.

Mechanism of action

Levodopa is a precursor to dopamine that crosses the blood-brain barrier. Carbidopa prevents peripheral metabolism of levodopa, increasing the amount available for dopamine conversion in the brain.

Sinemet

Indicated to manage Parkinson’s disease, this combination therapy is utilized to support motor function by replacing depleted dopamine in the central nervous system.

Editorial Notes

  • Active ingredient(s): Carbidopa, Levodopa
  • Listed indication(s): Parkinson’s Disease

Usually available as

  • 180 tablets - 10/100 mg139-10-100-mg-4168
  • 120 tablets - 25/100 mg139-25-100-mg-4173
  • 90 tablets - 25/250 mg139-25-250-mg-4178