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Medicine details

Conditions: Malaria
Alternative names: Avloclor; Nivaquine
Therapeutic class: Antimalarial
Pharmacological class: Aminoquinoline
Known off-label uses: rheumatoid arthritis; systemic lupus erythematosus
Contraindications: retinal damage; hypersensitivity; pre-existing visual field changes
Minor side effects: nausea; headache; diarrhoea
Moderate side effects: skin pigmentation; rash; visual disturbance
Dosage forms: Tablet
Administration route: Oral use
Patient summary: Formulated to treat malaria to mitigate parasitic infection in the blood.
Prescription status: POM
Manufacturer: Sanofi
Onset Time: 1–2 hours
Duration: varies by treatment length
Storage instructions: Store below 25°C.
Drug interactions: Ciclosporin; Tamoxifen
Age restrictions: Safe for use in children if dosed by weight.

Precautions and warnings

routine eye examinations required; use with caution in psoriasis; may cause cardiac conduction issues

Serious side effects

retinopathy — requires immediate medical attention; qt interval prolongation — requires immediate medical attention

Mechanism of action

This medication functions by interfering with the growth of parasites in the red blood cells, effectively eradicating the malaria-causing organisms.

Pregnancy and breastfeeding

Pregnancy: Use is acceptable for malaria treatment where benefit outweighs risk. Breastfeeding: Safe in recommended doses.

Formulated to treat malaria to mitigate parasitic infection in the blood.