Thorazine
intended to address severe psychiatric symptoms by modulating dopaminergic pathways in the brain.
Strengths: 50 · 100mg
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Medicine details
- Alternative names
Largactil
- Therapeutic class
Typical Antipsychotic
- Pharmacological class
Phenothiazine
- Precautions and warnings
avoid sun and UV exposure; may impair motor coordination
- Minor side effects
drowsiness; dry mouth; constipation
- Moderate side effects
dystonia; hypotension; blurred vision
- Dosage forms
Film-coated tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
GSK
- Onset Time
30–60 minutes
- Duration
4–6 hours
- Storage instructions
Store in a light-resistant container at room temperature.
- Drug interactions
alcohol; sedatives; lithium
- Age restrictions
Use with extreme caution in geriatric patients.
- Pregnancy and breastfeeding
Pregnancy: Risk to fetus; consult specialist. Breastfeeding: Not recommended.
Contraindications
hypersensitivity to phenothiazines; central nervous system depression; coma; severe blood dyscrasias
Serious side effects
tardive dyskinesia — requires immediate medical attention; neuroleptic malignant syndrome — requires immediate medical attention
Patient summary
intended to address severe psychiatric symptoms by modulating dopaminergic pathways in the brain.
Mechanism of action
Thorazine acts primarily as an antagonist at postsynaptic dopamine receptors in the limbic system, hypothalamus, and basal ganglia. By blocking these receptors, it reduces the hyperactivity associated with psychotic conditions and helps regain stability in neurotransmitter signaling.
Thorazine
intended to address severe psychiatric symptoms by modulating dopaminergic pathways in the brain.
Editorial Notes
- Active ingredient(s): Chlorpromazine
- Listed indication(s): Schizophrenia, Psychotic Disorders, Nausea and Vomiting
Usually available as
- 360 tablets - 50 mg666-50-mg-4317
- 360 tablets - 100 mg666-100-mg-4323