Compazine
intended to mitigate nausea and vomiting and to target the vestibular system to manage vertigo-related symptoms.
Strengths: 5mg
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Medicine details
- Alternative names
Stemetil
- Therapeutic class
Phenothiazine Antipsychotic
- Pharmacological class
Dopamine Antagonist
- Known off-label uses
anxiety
- Contraindications
circulatory collapse; severe central nervous system depression
- Precautions and warnings
may cause drowsiness; use with caution in elderly patients
- Minor side effects
drowsiness; dizziness; dry mouth
- Moderate side effects
extrapyramidal symptoms; tachycardia; blurred vision
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Sanofi
- Onset Time
30–60 minutes
- Duration
4–6 hours
- Storage instructions
Keep at room temperature.
- Drug interactions
alcohol; sedatives; opioids
- Age restrictions
Not recommended for children under 2 years.
Serious side effects
neuroleptic malignant syndrome — requires immediate medical attention; tardive dyskinesia — requires immediate medical attention; agranulocytosis — requires immediate medical attention
Patient summary
intended to mitigate nausea and vomiting and to target the vestibular system to manage vertigo-related symptoms.
Mechanism of action
Prochlorperazine acts centrally by blocking dopamine receptors in the brain's chemoreceptor trigger zone. This action suppresses the signaling pathway that triggers nausea and vomiting reflexes.
Pregnancy and breastfeeding
Should be avoided during pregnancy unless clearly necessary. Breastfeeding: May be used if clinically indicated; monitor infant.
Compazine
intended to mitigate nausea and vomiting and to target the vestibular system to manage vertigo-related symptoms.
Editorial Notes
- Active ingredient(s): Prochlorperazine
- Listed indication(s): Nausea, Vomiting, Vertigo
Available option
- 360 tablets - 5 mg288-5-mg-2521