Isosorbide Tablets
Indicated to target angina and developed to alleviate chest pain, this nitrate is utilized to support cardiac vasomotor function.
Strengths: 20 · 30 · 40 · 60mg
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Medicine details
- Conditions
- Alternative names
Imdur; Monosorb; Isotard
- Therapeutic class
Nitrate vasodilator
- Pharmacological class
Organic nitrate
- Minor side effects
headache; flushing; dizziness
- Moderate side effects
tachycardia; postural hypotension; nausea
- Dosage forms
Tablet; Prolonged-release tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
AstraZeneca
- Onset Time
30–60 minutes
- Duration
8–12 hours
- Storage instructions
Store in original packaging below 25°C.
- Drug interactions
sildenafil; tadalafil; alcohol
- Age restrictions
Consult specialist regarding paediatric use.
Contraindications
hypersensitivity to nitrates; concurrent use of phosphodiesterase-5 inhibitors; severe hypotension; cardiogenic shock
Precautions and warnings
avoid sudden change in posture to prevent dizziness; may impair ability to drive; do not discontinue abruptly
Serious side effects
syncope — requires immediate medical attention; myocardial ischaemia — requires immediate medical attention; severe hypotension — requires immediate medical attention
Patient summary
Indicated to target angina and developed to alleviate chest pain, this nitrate is utilized to support cardiac vasomotor function.
Mechanism of action
Isosorbide mononitrate is a vasodilator that acts by releasing nitric oxide, which stimulates guanylyl cyclase. This increases cellular cGMP concentrations, resulting in smooth muscle relaxation in blood vessels, thereby reducing cardiac workload and oxygen demand.
Pregnancy and breastfeeding
Pregnancy: Use only if benefit outweighs risk. Breastfeeding: Suitable with caution.
Isosorbide Tablets
Indicated to target angina and developed to alleviate chest pain, this nitrate is utilized to support cardiac vasomotor function.
Editorial Notes
- Active ingredient(s): Isosorbide Mononitrate
- Listed indication(s): Angina Pectoris
Usually available as
- 180 tablets - 20 mg1398-20-mg-16780
- 120 tablets - 30 mg1398-30-mg-16785
- 120 tablets - 40 mg1398-40-mg-16774