Furadantin
formulated to treat urinary tract infections to mitigate bacterial colonization in the bladder.
Strengths: 50 · 100mg
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Medicine details
- Conditions
- Alternative names
Macrobid; Macrodantin
- Therapeutic class
Antibacterial; Nitrofuran
- Pharmacological class
Nitrofuran Antibiotic
- Known off-label uses
urinary tract infection prophylaxis
- Minor side effects
nausea; headache; flatulence
- Moderate side effects
diarrhoea; abdominal pain
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Alvogen
- Onset Time
1–2 hours
- Duration
3–7 days
- Storage instructions
Store in its original packaging at room temperature away from moisture.
- Drug interactions
antacids containing magnesium trisilicate; probenecid
- Age restrictions
Suitable for children and adults; dosage adjusted for body weight.
Contraindications
hypersensitivity to nitrofurantoin; anuria; oliguria; renal impairment; g6pd deficiency
Precautions and warnings
may discolour urine; monitor for pulmonary respiratory symptoms; use with caution in elderly patients
Serious side effects
peripheral neuropathy — requires immediate medical attention; pulmonary fibrosis — requires immediate medical attention; hepatitis — requires immediate medical attention
Patient summary
formulated to treat urinary tract infections to mitigate bacterial colonization in the bladder.
Mechanism of action
Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates that inactivate or alter bacterial ribosomal proteins and other macromolecules. This action inhibits aerobic energy metabolism and protein synthesis, resulting in bactericidal activity specifically within the urinary tract.
Pregnancy and breastfeeding
Pregnancy: Can be used if benefits outweigh risks, but avoid at term due to risk of neonatal haemolytic anaemia. Breastfeeding: Can be used with caution during breastfeeding.
Furadantin
formulated to treat urinary tract infections to mitigate bacterial colonization in the bladder.
Editorial Notes
- Active ingredient(s): Nitrofurantoin
- Listed indication(s): Cystitis, Urinary Tract Infection
Usually available as
- 200 tablets - 50 mg749-50-mg-13310
- 180 tablets - 100 mg749-100-mg-1147