Fluticasone + Salmeterol

Indicated to manage asthma and chronic obstructive pulmonary disease and to alleviate respiratory inflammation by opening airways and reducing swelling.

Strengths: 250/50 · 500/50mcg

Respiratory Health icon Respiratory Health Fluticasone Propionate icon Fluticasone Propionate Salmeterol icon Salmeterol

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Medicine details

Conditions
Alternative names

Seretide

Therapeutic class

Selective Beta2-Agonist/Corticosteroid Combination

Pharmacological class

Corticosteroid; Beta2-Agonist

Contraindications

hypersensitivity to components

Minor side effects

hoarseness; throat irritation; headache

Moderate side effects

oral candidiasis; muscle tremors; palpitations

Dosage forms

Inhalation powder

Administration route

Inhalation use

Prescription status

POM

Manufacturer

GSK

Onset Time

30 minutes (onset) to 1 week (consistency)

Duration

12 hours

Storage instructions

Store in a dry cool place.

Drug interactions

beta-blockers; ritonavir

Age restrictions

Use per age-appropriate device indication.

Pregnancy and breastfeeding

Pregnancy: Use only if necessary. Breastfeeding: Generally considered low risk.

Precautions and warnings

rinse mouth after use to prevent thrush; monitor for systemic corticosteroid effects; regular heart function assessment recommended

Serious side effects

paradoxical bronchospasm — requires immediate medical attention; severe allergic reaction — requires immediate medical attention

Patient summary

Indicated to manage asthma and chronic obstructive pulmonary disease and to alleviate respiratory inflammation by opening airways and reducing swelling.

Mechanism of action

This combination provides long-acting bronchodilation via salmeterol, which relaxes airway smooth muscles, and anti-inflammatory activity via fluticasone, which reduces airway hyper-responsiveness.

Fluticasone + Salmeterol

Indicated to manage asthma and chronic obstructive pulmonary disease and to alleviate respiratory inflammation by opening airways and reducing swelling.

Editorial Notes

  • Active ingredient(s): Fluticasone Propionate, Salmeterol
  • Listed indication(s): Asthma, Chronic Obstructive Pulmonary Disease

Usually available as

  • 3 inhalers - 250/50 mcg1139-250-50-mcg-13511
  • 2 inhalers - 500/50 mcg1139-500-50-mcg-13507