Disulfiram Tablets
The product is intended to relieve cravings and facilitate behavioral change in alcohol cessation therapy.
Strengths: 250 · 500mg
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Medicine details
- Conditions
- Alternative names
Antabuse
- Therapeutic class
Aldehyde Dehydrogenase Inhibitor
- Pharmacological class
Aldehyde Dehydrogenase Inhibitor
- Precautions and warnings
liver function monitoring required; carry identification card
- Minor side effects
drowsiness; metallic taste; headache
- Moderate side effects
acne; mild neuropathy
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Concordia International
- Onset Time
12–24 hours
- Duration
up to 14 days
- Storage instructions
Store below 25°C in original packaging.
- Drug interactions
Alcohol; Metronidazole; Phenytoin
- Age restrictions
Adult use only.
- Pregnancy and breastfeeding
Pregnancy: Generally not recommended. Breastfeeding: Unknown safety profile.
Contraindications
hypersensitivity to disulfiram; severe heart disease; psychosis; alcohol intake within 24 hours
Serious side effects
hepatitis — requires immediate medical attention; psychotic reaction — requires immediate medical attention
Patient summary
The product is intended to relieve cravings and facilitate behavioral change in alcohol cessation therapy.
Mechanism of action
Disulfiram inhibits the enzyme aldehyde dehydrogenase, which causes an accumulation of acetaldehyde in the blood if alcohol is consumed, resulting in severe physiological discomfort and deterring alcohol intake.
Disulfiram Tablets
The product is intended to relieve cravings and facilitate behavioral change in alcohol cessation therapy.
Editorial Notes
- Active ingredient(s): Disulfiram
- Listed indication(s): Alcohol Dependence
Available option
- 360 tablets - 250 mg1147-250-mg-13579