Antabuse
This agent is utilized to support addiction recovery and is indicated to address alcohol consumption by inducing sensitivity.
Strengths: 250 · 500mg
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Medicine details
- Conditions
- Therapeutic class
Aldehyde Dehydrogenase Inhibitor
- Pharmacological class
Aldehyde Dehydrogenase Inhibitor
- Precautions and warnings
monitor liver function regularly
- Minor side effects
drowsiness; fatigue; metallic taste; headache
- Moderate side effects
skin rash; diarrhoea
- Dosage forms
Tablet; Effervescent tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Advanz Pharma
- Onset Time
Variable
- Duration
3–14 days
- Storage instructions
Store at room temperature.
- Drug interactions
alcohol; metronidazole; warfarin; phenytoin
- Age restrictions
Not recommended for children.
- Pregnancy and breastfeeding
Pregnancy: Not recommended. Breastfeeding: Not recommended.
Contraindications
severe heart disease; psychosis; hypersensitivity to thiuram derivatives; concurrent alcohol use
Serious side effects
hepatitis — requires immediate medical attention; polyneuropathy — requires immediate medical attention; psychotic reaction — requires immediate medical attention
Patient summary
This agent is utilized to support addiction recovery and is indicated to address alcohol consumption by inducing sensitivity.
Mechanism of action
Disulfiram interferes with the metabolism of alcohol by blocking the enzyme aldehyde dehydrogenase. This results in the accumulation of acetaldehyde in the body, causing unpleasant physical reactions when alcohol is consumed, thereby deterring alcohol intake.
Antabuse
This agent is utilized to support addiction recovery and is indicated to address alcohol consumption by inducing sensitivity.
Editorial Notes
- Active ingredient(s): Disulfiram
- Listed indication(s): Alcohol Dependence
Usually available as
- 180 tablets - 250 mg431-250-mg-2024
- 180 tablets - 500 mg431-500-mg-2030