Bupropion + Naltrexone Tablets

Formulated to target appetite centres in the brain, this combination is utilized to support weight management and alleviate persistent hunger sensations.

Strengths: 8/90mg

Weight Management icon Weight Management Addiction Recovery icon Addiction Recovery Bupropion icon Bupropion Naltrexone icon Naltrexone

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Medicine details

Conditions
Alternative names

Mysimba; Contrave

Therapeutic class

Weight Loss Agent

Pharmacological class

Antiobesity Agent

Precautions and warnings

monitor blood pressure; check for depression symptoms

Minor side effects

nausea; constipation; headache; vomiting

Moderate side effects

dizziness; insomnia; dry mouth

Dosage forms

Prolonged-release tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Orexigen Therapeutics

Onset Time

1–2 weeks

Duration

24 hours

Storage instructions

Store below 25°C.

Drug interactions

opioids; alcohol; maois

Age restrictions

Not for children under 18.

Pregnancy and breastfeeding

Pregnancy: Contraindicated. Breastfeeding: Not recommended.

Contraindications

hypersensitivity to components; uncontrolled hypertension; seizure disorders; eating disorders; bipolar disorder

Serious side effects

seizure — requires immediate medical attention; anaphylaxis — requires immediate medical attention

Patient summary

Formulated to target appetite centres in the brain, this combination is utilized to support weight management and alleviate persistent hunger sensations.

Mechanism of action

This treatment combines two agents that act on the central nervous system. Bupropion acts as a dopamine and noradrenaline reuptake inhibitor, while naltrexone is an opioid antagonist. Together, they target the hypothalamus and the mesolimbic dopamine circuit to reduce appetite and manage cravings.

Bupropion + Naltrexone Tablets

Formulated to target appetite centres in the brain, this combination is utilized to support weight management and alleviate persistent hunger sensations.

Editorial Notes

  • Active ingredient(s): Bupropion, Naltrexone
  • Listed indication(s): Obesity

Available option

  • 60 tablets - 8/90 mg1238-8-90-mg-14800