monitor for liver function; use caution in severe hepatic impairment; discontinue if symptoms of colitis arise

clostridioides difficile-associated diarrhoea — requires immediate medical attention

utilized to support the treatment of hepatic encephalopathy and intended to target bacterial overgrowth within the gastrointestinal tract.

Rifaximin is a non-systemic rifamycin antibiotic that binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting RNA synthesis. It exhibits broad-spectrum activity against gastrointestinal pathogens and modulates intestinal microbiota to reduce ammonia production.

Pregnancy: Not recommended unless necessary due to lack of clinical data. Breastfeeding: Advise caution as systemic absorption is low but potential for excretion exists.