Tolvaptan Tablets
This medicine is indicated to manage hyponatraemia and utilized to address fluid imbalance in patients with low sodium levels.
Strengths: 15 · 30mg
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Medicine details
- Conditions
- Alternative names
Samsca
- Therapeutic class
Vasopressin antagonist
- Pharmacological class
Vasopressin V2 receptor antagonist
- Minor side effects
thirst; dry mouth; polyuria; pollakiuria
- Moderate side effects
hypernatraemia; dehydration; constipation; fatigue
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Otsuka Pharmaceutical
- Onset Time
2–4 hours
- Duration
24 hours
- Storage instructions
Store in original packaging below 30°C.
- Drug interactions
strong CYP3A4 inhibitors; grapefruit juice
- Age restrictions
Not for use in children.
Contraindications
hypersensitivity to tolvaptan; hypovolaemic hyponatraemia; anuria; urinary retention
Precautions and warnings
monitor serum sodium levels; maintain adequate fluid intake; monitor liver function regularly
Serious side effects
hepatic injury — requires immediate medical attention; rapid correction of hyponatraemia — requires immediate medical attention
Patient summary
This medicine is indicated to manage hyponatraemia and utilized to address fluid imbalance in patients with low sodium levels.
Mechanism of action
Tolvaptan specifically blocks vasopressin V2 receptors in the kidney, promoting water excretion while retaining electrolytes to correct serum sodium levels.
Pregnancy and breastfeeding
Pregnancy: Use only if potential benefit outweighs risk. Breastfeeding: Avoid during treatment.
Tolvaptan Tablets
This medicine is indicated to manage hyponatraemia and utilized to address fluid imbalance in patients with low sodium levels.
Editorial Notes
- Active ingredient(s): Tolvaptan
- Listed indication(s): Hyponatraemia
Usually available as
- 20 tablets - 15 mg1328-15-mg-15917
- 20 tablets - 30 mg1328-30-mg-15925