Tofranil
This medication is developed to address symptoms of depression and utilized for children with nocturnal enuresis.
Strengths: 25 · 50 · 75mg
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Medicine details
- Conditions
- Therapeutic class
Tricyclic Antidepressant
- Pharmacological class
Tricyclic Antidepressant (TCA)
- Precautions and warnings
may impair driving; regular blood pressure monitoring
- Minor side effects
dry mouth; blurred vision; constipation; dizziness
- Moderate side effects
tachycardia; urinary retention; confusion
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Novartis
- Onset Time
2–4 weeks
- Duration
long-term
- Storage instructions
Store in a dry place.
- Drug interactions
Alcohol; MAO inhibitors; Antihypertensives
- Age restrictions
Used in children for enuresis.
- Pregnancy and breastfeeding
Pregnancy: use only if essential. Breastfeeding: contraindicated.
Contraindications
recent myocardial infarction; concurrent use of MAO inhibitors; prostatic hypertrophy
Serious side effects
cardiac arrhythmia — requires immediate medical attention; seizures — requires immediate medical attention
Patient summary
This medication is developed to address symptoms of depression and utilized for children with nocturnal enuresis.
Mechanism of action
Imipramine blocks the neuronal reuptake of norepinephrine and serotonin. This increases their availability in the synaptic cleft, exerting an antidepressant effect, while its anticholinergic effect helps manage bedwetting.
Tofranil
This medication is developed to address symptoms of depression and utilized for children with nocturnal enuresis.
Editorial Notes
- Active ingredient(s): Imipramine
- Listed indication(s): Major Depressive Disorder, Enuresis
Usually available as
- 360 tablets - 25 mg100-25-mg-4329
- 120 tablets - 75 mg100-75-mg-4336