Tapazole
developed to mitigate excessive thyroid hormone production for clinical stabilization.
Strengths: 5 · 10mg
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Medicine details
- Conditions
- Alternative names
Carbimazole
- Therapeutic class
Antithyroid Agent
- Pharmacological class
Thionamide
- Minor side effects
nausea; rash; arthralgia; headache
- Moderate side effects
jaundice; pruritus
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Eli Lilly
- Onset Time
30–60 minutes
- Duration
6–12 hours
- Storage instructions
Store at room temperature away from direct medical hazard.
- Drug interactions
warfarin; theophylline
- Age restrictions
Used with physician supervision in paediatric cases.
Contraindications
hypersensitivity to thionamides; severe hepatic impairment; history of bone marrow disorders
Precautions and warnings
report any signs of infection or sore throat immediately; monitor white blood cell count; use caution in pregnancy
Serious side effects
agranulocytosis — requires immediate medical attention; hepatitis — requires immediate medical attention; vasculitis — requires immediate medical attention
Patient summary
developed to mitigate excessive thyroid hormone production for clinical stabilization.
Mechanism of action
This medication functions by inhibiting the synthesis of thyroid hormones through the blockade of the enzyme thyroid peroxidase. This prevents the iodination of tyrosine residues, effectively reducing the levels of active thyroid hormones in the blood.
Pregnancy and breastfeeding
Pregnancy: Risk associated with first trimester use; doctor consultation essential. Breastfeeding: Use with caution.
Tapazole
developed to mitigate excessive thyroid hormone production for clinical stabilization.
Editorial Notes
- Active ingredient(s): Methimazole
- Listed indication(s): Hyperthyroidism