Methotrexate Tablets
Utilized to manage autoimmune responses and indicated to alleviate inflammation-related tissue damage effectively.
Strengths: 2.5mg
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Medicine details
- Alternative names
Maxtrex
- Therapeutic class
Antimetabolite
- Pharmacological class
Folic acid antagonist
- Contraindications
severe hepatic impairment; pregnancy; breastfeeding; severe renal impairment
- Precautions and warnings
regular blood monitoring required; photosensitivity precaution
- Minor side effects
nausea; abdominal pain; fatigue
- Moderate side effects
stomatitis; elevated liver enzymes
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Hospira
- Onset Time
3–6 weeks
- Duration
long-term
- Storage instructions
Store at room temperature in a safe place.
- Drug interactions
alcohol; nsaids; salicylates
- Age restrictions
Use with caution in elderly patients.
- Pregnancy and breastfeeding
Pregnancy: absolute contraindication. Breastfeeding: contraindicated.
Serious side effects
bone marrow suppression — requires immediate medical attention; hepatotoxicity — requires immediate medical attention
Patient summary
Utilized to manage autoimmune responses and indicated to alleviate inflammation-related tissue damage effectively.
Mechanism of action
Methotrexate inhibits dihydrofolate reductase, thereby interfering with DNA synthesis and cellular replication to suppress overactive immune responses in chronic inflammatory conditions.
Methotrexate Tablets
Utilized to manage autoimmune responses and indicated to alleviate inflammation-related tissue damage effectively.
Editorial Notes
- Active ingredient(s): Methotrexate
- Listed indication(s): Rheumatoid Arthritis, Psoriasis, Crohn’s Disease