Gleevec

designed to target cancer cells to alleviate disease progression.

Strengths: 100 · 400mg

designed to target cancer cells to alleviate disease progression.

Strengths: 100 · 400mg

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Conditions: Chronic Myeloid Leukaemia
Gastrointestinal Stromal Tumour
Alternative names: Glivec
Therapeutic class: Tyrosine Kinase Inhibitor
Pharmacological class: Tyrosine Kinase Inhibitor
Contraindications: hypersensitivity to imatinib
Minor side effects: nausea; muscle cramps; oedema; fatigue
Moderate side effects: diarrhoea; headache; neutropaenia
Dosage forms: Film-coated tablet
Administration route: Oral use
Patient summary: designed to target cancer cells to alleviate disease progression.
Prescription status: POM
Manufacturer: Novartis
Onset Time: 2–4 hours
Duration: 24 hours
Storage instructions: Store below 30°C.
Drug interactions: Ketoconazole; Warfarin; Grapefruit
Age restrictions: Used in children with specific leukaemic conditions.
Pregnancy and breastfeeding: Pregnancy: must not be used. Breastfeeding: not recommended.

Precautions and warnings

monitor blood counts regularly; avoid pregnancy during treatment; monitor liver function

Serious side effects

congestive heart failure — requires immediate medical attention; severe gastrointestinal haemorrhage — requires immediate medical attention

Mechanism of action

This medicine is a tyrosine kinase inhibitor that blocks specific proteins involved in the signalling pathways of cancer cell growth and survival.

designed to target cancer cells to alleviate disease progression.

Active ingredient(s): Imatinib
Listed indication(s): Chronic Myeloid Leukaemia, Gastrointestinal Stromal Tumour