Endep

This medicine is indicated for depressive disorders utilized to alleviate persistent neuropathic pain for patients requiring structured therapeutic support.

Strengths: 10 · 25 · 50 · 75mg

Antidepressants icon Antidepressants Amitriptyline icon Amitriptyline

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Medicine details

Conditions
Alternative names

Tryptizol

Therapeutic class

Tricyclic Antidepressant

Pharmacological class

TCA

Known off-label uses

migraine prophylaxis

Contraindications

hypersensitivity to amitriptyline; recent myocardial infarction; arrhythmia

Minor side effects

dry mouth; drowsiness; dizziness

Moderate side effects

blurred vision; urinary retention; constipation

Dosage forms

Film-coated tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

AstraZeneca

Onset Time

2–4 weeks

Duration

24 hours

Storage instructions

Store at room temperature in a cool, dry place away from direct sunlight.

Drug interactions

Alcohol; MAO inhibitors

Age restrictions

Not recommended for children and adolescents.

Precautions and warnings

may impair ability to drive or operate machinery; use with caution in elderly patients

Serious side effects

suicidal ideation — requires immediate medical attention; cardiac arrhythmia — requires immediate medical attention

Patient summary

This medicine is indicated for depressive disorders utilized to alleviate persistent neuropathic pain for patients requiring structured therapeutic support.

Mechanism of action

Amitriptyline acts by inhibiting the reuptake of neurotransmitters, specifically serotonin and norepinephrine, within the central nervous system. This enhances synaptic concentrations of these chemicals, helping to stabilize mood and modulate pain signaling pathways effectively.

Pregnancy and breastfeeding

Pregnancy: Use only if clearly necessary after medical assessment. Breastfeeding: Small amounts pass into milk; consult your doctor for guidance.

Endep

This medicine is indicated for depressive disorders utilized to alleviate persistent neuropathic pain for patients requiring structured therapeutic support.

Editorial Notes

  • Active ingredient(s): Amitriptyline
  • Listed indication(s): Major Depressive Disorder, Neuropathic Pain

Usually available as

  • 360 tablets - 10 mg438-10-mg-2855
  • 180 tablets - 25 mg438-25-mg-2860
  • 90 tablets - 50 mg438-50-mg-2863