Vfend

Developed to target serious fungal infections, this medication is indicated to address invasive aspergillosis and is utilized in systemic treatment protocols.

Strengths: 200mg

Antifungals icon Antifungals Voriconazole icon Voriconazole

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Medicine details

Conditions
Therapeutic class

Triazole Antifungal

Pharmacological class

Antifungal

Precautions and warnings

avoid prolonged sun exposure; monitor liver function; monitor visual function

Minor side effects

visual disturbances; nausea; vomiting; rash

Moderate side effects

elevated liver enzymes; peripheral oedema; headache

Dosage forms

Film-coated tablet

Administration route

Oral use

Prescription status

POM

Manufacturer

Pfizer

Onset Time

1–2 hours

Duration

12 hours

Storage instructions

Store at room temperature.

Drug interactions

rifampicin; carbamazepine; pimozide; quinidine

Age restrictions

Use with caution in paediatric patients.

Contraindications

hypersensitivity to voriconazole; concurrent use of rifampicin; concurrent use of carbamazepine

Serious side effects

hepatotoxicity — requires immediate medical attention; photosensitivity — requires immediate medical attention; qt prolongation — requires immediate medical attention

Patient summary

Developed to target serious fungal infections, this medication is indicated to address invasive aspergillosis and is utilized in systemic treatment protocols.

Mechanism of action

Voriconazole inhibits fungal cytochrome P450-dependent 14-alpha-sterol demethylase, which is vital for fungal ergosterol biosynthesis, effectively disrupting fungal cell membrane formation.

Pregnancy and breastfeeding

Pregnancy: Use is not recommended unless clearly necessary. Breastfeeding: Discontinue breastfeeding during treatment.

Vfend

Developed to target serious fungal infections, this medication is indicated to address invasive aspergillosis and is utilized in systemic treatment protocols.

Editorial Notes

  • Active ingredient(s): Voriconazole
  • Listed indication(s): Invasive Aspergillosis, Candidemia, Oesophageal Candidiasis

Available option

  • 4 tablets - 200 mg1087-200-mg-14999