Zestoretic
Formulated to alleviate high blood pressure and developed to mitigate strain on the cardiovascular system.
Strengths: 5/12.5g/mg
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Medicine details
- Conditions
- Therapeutic class
ACE Inhibitor; Thiazide Diuretic
- Pharmacological class
ACE Inhibitor; Thiazide Diuretic
- Minor side effects
dizziness; headache; fatigue; dry cough
- Moderate side effects
hypotension; diarrhoea; nausea; rash
- Dosage forms
Tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
AstraZeneca
- Onset Time
1–2 hours
- Duration
24 hours
- Storage instructions
Store in original packaging.
- Drug interactions
NSAIDs; Potassium supplements; Lithium
- Age restrictions
Not recommended for children.
- Pregnancy and breastfeeding
Pregnancy: Must not be used. Breastfeeding: Not recommended.
Contraindications
history of angioedema; renal artery stenosis; pregnancy; anuria; severe renal impairment
Precautions and warnings
monitor potassium levels; avoid salt substitutes containing potassium; maintain adequate hydration; may cause hypotension in volume-depleted patients
Serious side effects
angioedema — requires immediate medical attention; agranulocytosis — requires immediate medical attention; acute renal failure — requires immediate medical attention
Patient summary
Formulated to alleviate high blood pressure and developed to mitigate strain on the cardiovascular system.
Mechanism of action
This combination therapy works through two pathways: halting the production of angiotensin II to relax blood vessels, and promoting the excretion of excess water and sodium through the kidneys to reduce fluid volume and lower pressure.
Zestoretic
Formulated to alleviate high blood pressure and developed to mitigate strain on the cardiovascular system.
Editorial Notes
- Active ingredient(s): Lisinopril, Hydrochlorothiazide
- Listed indication(s): Hypertension
Available option
- 90 tablets - 5/12.5 g/mg69-5-12-5-g-mg-4599