Isoptin Sr
formulated to mitigate cardiac workload and lower systemic blood pressure through ion channel inhibition.
Strengths: 120 · 240mg
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Medicine details
- Conditions
- Alternative names
Cordilox; Securon
- Therapeutic class
Calcium Channel Blocker
- Pharmacological class
Phenylalkylamine
- Minor side effects
constipation; dizziness; nausea
- Moderate side effects
peripheral oedema; bradycardia; hypotension
- Dosage forms
Modified-release tablet
- Administration route
Oral use
- Prescription status
POM
- Manufacturer
Mylan
- Onset Time
1–2 hours
- Duration
12–24 hours
- Storage instructions
Store below 25°C, keep dry.
- Drug interactions
grapefruit juice; beta blockers; st. john's wort
- Age restrictions
Not indicated for infants.
Contraindications
hypersensitivity to verapamil; severe left ventricular dysfunction; atrioventricular block
Precautions and warnings
monitor liver function with long use; report constipation; avoid rapid withdrawal
Serious side effects
complete atrioventricular block — requires immediate medical attention; cardiac failure — requires immediate medical attention
Patient summary
formulated to mitigate cardiac workload and lower systemic blood pressure through ion channel inhibition.
Mechanism of action
Isoptin Sr works by blockading transmembrane calcium ion influx in cardiac and vascular smooth muscle membranes. This reduces peripheral resistance, lowers blood pressure, and slows conduction through the AV node, providing rhythm control and angina relief.
Pregnancy and breastfeeding
Pregnancy: Consult physician regarding risks. Breastfeeding: Present in small amounts in breast milk.
Isoptin Sr
formulated to mitigate cardiac workload and lower systemic blood pressure through ion channel inhibition.
Editorial Notes
- Active ingredient(s): Verapamil
- Listed indication(s): Hypertension, Angina Pectoris, Arrhythmia
Usually available as
- 180 tablets - 120 mg673-120-mg-3277
- 120 tablets - 240 mg673-240-mg-3282